Salbutamol residues in swine tissues and body fluids after feeding

Abstract

Salbutamol residues in swine tissues and fluids were investigated. Tissue, serum and urine samples were collected from 33 pigs after 14 days of oral administration of 3 ppm salbutamol. The concentrations of salbutamol were determined by enzyme-linked immunosorbent assay and further confirmed by capillary electrophoresis. The highest urinary concentration of salbutamol was 145.12 ng/ml at 18 hour and remained detectable for 30 days after the last feeding. Salbutamol was undetectable in serum samples. The highest concentrations of salbutamol in liver, kidney, lung, heart, brain and muscle were 70.42 ng/g, 31.88 ng/g, 26.06 ng/g, 6.76 ng/g, 3.41 ng/g and 2.97 ng/g, respectively. Stomach and large intestine retained salbutamol residue for 11 days which is longer than those in the liver, lung, brain (4 days) and other tissues (2 days). The data shown in this study will be helpful for the screening of salbutamol residues and regulations on its illegal use in pigs.