Sensitive Spectrophotometric and Conductometric Methods for the Determination of Candesartan Using Acidic Dyes

Abstract

Two simple, sensitive, accurate, rapid spectrophotometric and conductometric methods were developed for the determination of candesartan (CAND) in raw material and in its pharmaceutical preparation. The proposed methods depend upon the reaction of bromocresol green (BCG) or bromocresol purple (BCP) with candesartan in phosphate buffered solution to form stable colored ion-pair complex, which was extracted in chloroform. The yellow colored complexes were determined at λmax 415, 405 nm with BCG, BCP, respectively. Using conductometric titration, candesartan could be evaluated in acetone. The optimizations of various experimental conditions were described. The results obtained showed good recover of 100.14 (n=6) with relative standard deviation of 0.62 (n=6). Applications of the proposed methods to representative pharmaceutical formulations are successfully presented compared with official methods.