Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro

Abstract

Objective . This study examines the effects of iron ions Fe 3+ on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an in vitro model of iron overload in end-stage renal disease (ESRD). Material and Methods . Respiratory burst of peritoneal phagocytes was measured by chemiluminescence method. Results . At the highest used concentration of iron ions Fe 3+ (100 μM), free radicals production by peritoneal phagocytes was reduced by 90% compared to control. Conclusions . Iron overload may increase the risk of infectious complications in ESRD patients.