Interaction between cisplatin, 5-fluorouracil and vincristine on human hepatoma cell line (7721)

Abstract

AIM: To evaluate the killing effects of CDDP, 5-Fu and VCR on human hepatoma cell line (7721). METHODS: The median-effect principle was used. RESULTS: Killing effects of the individual drug were enhanced as the median concentration increased. Antagonism was produced when two drugs were used at a higher concentration (Cl> 1), and synergism was achieved when Cl < 1. Finally, the effect was influenced by both the ratios of drug concentration and the sequence of administration. CONCLUSION: The drug administration order and drug concentrations are significant factors that need to be considered in clinical practice.