Determination of Paracetemol in Pharmaceutical Preparations Samples by Spectrophotometer using Meta Phenylenediamine as a Chromogenic Agent

Abstract

Paracetamol, which first formulated into pharmaceutical formulations by Von Mering in 1893, is also known as acetaminophen is present in most antipyretic and analgesic medicines. A significant analytical concern is the development of experimental analytical methods for the quick and selective determination of Paracetemol in active pharmaceutical ingredients. The paracetamol (PCTL) determination method was explicitly described; the optimal reaction method conditions, i.e. the oxidative coupling method, were as follows: 0.76 mM hexacyanoferrate concentration, 3.8 mM potassium hydroxide, and 0.095 mM m-phenylenediamine (MPDA), 0.05 mM PCTL concentration. In order to approve the performance of the methods, the linearity, coefficient correlation, precision, and accuracy were evaluated. The procedure for evaluating PCTL in skeletal muscle relaxant samples is highly applicable.