Mouse bioassay for Fusarium metabolites: rejection or acceptance when dissolved in drinking water

Abstract

Ten metabolites of Fusarium species (butenolide, diacetoxyscirpenol, equisetin, fusaric acid, gibberellic acid, moniliformin, NRRL 6227 peptide, T-2 toxin, vomitoxin, and zearalenone) were added to the drinking water of mice to determine whether they were consumed or refused. Of the 10, only the trichothecenes - diacetoxyscirpenol, T-2 toxin, and vomitoxin - were refused. Refusal of 2 mg of the trichothecenes per liter was not enhanced by adding 100 mg of zearalenone per liter.