0782 Circadian Rhythm Sleep Disorders And Their Predictors Among Children With Autism - A Prospective Case Control Study.

Abstract

Introduction: While sleep disturbances have been widely reported among children with Autism spectrum disorders (ASD), there are fewer reports addressing and objectively assessing circadian sleep wake rhythm abnormalities in this population. This study was conducted with the objective of characterizing various circadian sleep wake rhythm disorders (CRSD)and predictors thereof among children with ASD. Method(s): Children aged 3-12 years, with ASD (group 1) and age matched controls (group 2) were enrolled. Following informed consent from parent(s), each participant underwent administration of the Vinland Social Maturity Scale, Developmental Profile 3, and Childhood Autism rating scale-2. Sleep evaluation tools included Brief Infant sleep Questionnaire(BISQ), Child sleep habits questionnaire and Pediatric Sleep questionnaire. Actigraphy was conducted for at least for 10 consecutive days for all participants. Diagnosis of CRSDs was based on ICSD - 3. Subjects with Sleep onset delay >= 2 hours; average night time sleep duration < 5 hours; average duration of day time naps >= than 2 hours or mean total (24 hour) sleep duration < 8 hours were classified as CRSD-unspecified. Result(s): We recruited 32 children in each group with similar mean age[7.15+/-3 vs 8.09+/-3.1, p =0.23] and gender[27(84%) vs. 23(72%) males, p=0.22]. CRSDs prevalence was significantly higher in group 1 [20/32(62.5%)]; than in group 2[2/32 (6.25%)] ( p=