Scoping Review: Pengaruh Paparan Bensin terhadap Kadar ALT dan AST pada Pekerja SPBU

Abstract

Gasoline exposure often associated to adverse health effects including hepatic injury. Petrol station attendants are the most risky exposed to gasoline by inhalation due to occupational. Hepatic injury may be identified by examining the liver function such as liver enzyme, ALT and AST. This study aims to determine effect gasoline exposure on AST and ALT levels in petrol station attendants. This research method used Scoping Review by identifying, analyzing, and evaluating scientific publication articles that is in accordance with the inclusion and exclusion criteria, eligibility criteria thus eleven articles were obtained. Keyword used are “Gasoline workers” AND “ALT”, articles relevant to petrol station attendants population, gasoline exposure, control group, and ALT and AST levels. This research was conducted from October to December 2020. The result showed from eleven articles, four articles reported there was a significant differences in AST and ALT, two articles reported there was significant difference in ALT, and five articles reported there was no significant change in ALT nor AST. The conclusion of this study is difference in result may be influenced by other factor such as variation, duration, concentration of exposed fuel, method used, age, sex, smoking, alcohol consumption or neglect of personal protective equipment, massive cell destruction, also liver cell regeneration may take a role