Inhibitors of Adenosine 3′,5′-Cyclic Monophosphate Phosphodiesterase in Cassia Seed

Abstract

Aurantio-obtusin and obtusin were identified as inhibitors of adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase in seeds of Cassia obtusifolia L. and Cassia tora L. The structure-activity relationships of 22 anthraquinones and 17 analogous compounds were studied. Anthraquinones of the emodin and obtusin types were generally more inhibitory towards cAMP phosphodiesterase than other types of anthraquinones. anthrones and lactones. © 1984, The Pharmaceutical Society of Japan. All rights reserved.