Antiviral activity of polyoxomol ybdoeuropate pm-104 against human immunodeficiency virus type 1

Abstract

A polyoxomolybdoeuropate PM-104 (NH4)12H2[Eu4(Mo04)(H20)i6(Mo7024)4]-13H20 was found to be a potent inhibitor of the growth of human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS). On the basis of T150 [median cytotoxic concentration (CC5o)/median effective concentration (EC5o)L the in vitro anti-HIV-l activity of PM-104 is favorably comparable to that of a heteropolyoxotungstate PM-19 K7[PTi2Wi0O40]-6H20, which is one of the most potent HIV-1 inhibitors among the polyoxometalates so far tested. The heteropolyoxomolybdate with a potent anti-HIV-1 activity is introduced for the first time in this communication. © 1991, The Pharmaceutical Society of Japan. All rights reserved.