A convenient synthesis of benzo[c]phenanthridine alkaloid, chelerythrine, by the palladium-assisted internal biaryl coupling reaction

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Abstract

Total synthesis of chelerythrine, a benzo[c]phenanthridine alkaloid, was accomplished via the internal aryl-aryl coupling reaction of halo-amide (4) by the palladium-assisted cyclization reaction.

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Harayama, T., Akiyama, T., & Kawano, K. (1996). A convenient synthesis of benzo[c]phenanthridine alkaloid, chelerythrine, by the palladium-assisted internal biaryl coupling reaction. Chemical and Pharmaceutical Bulletin, 44(8), 1634–1636. https://doi.org/10.1248/cpb.44.1634

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