Neutrophils: "Neu players" in antibody therapy?

Abstract

In this issue of Blood, Albanesi et al have added weight to the contention that neutrophils are an important effector population in monoclonal antibody (mAb)-mediated tumor cell clearance. Their data, obtained using subcutaneous tumor models and an extensive panel of genetically modified mice, demonstrate that neutrophils are required for mAb efficacy and that they do so through a Syk-dependent Fcγ receptor (FcγR)-mediated mechanism. © 2013 by The American Society of Hematology.