The effects of sleeve gastrectomy on renal function in diabetic and non-diabetic morbidly obese patients

Abstract

Introduction: Obesity is associated with albuminuria and impaired renal function. Bariatric surgery improves and resolves diabetes and restores renal function in patients with morbid obesity. Objectives: This study investigates and compares the potential effects of sleeve gastrectomy on improving renal function and albuminuria in diabetic and non-diabetic morbidly obese patients. Patients and Methods: This prospective study included 137 morbidly obese individuals (44 diabetics and 93 non-diabetic) who underwent laparoscopic sleeve gastrectomy. The patients were evaluated clinically (anthropometric measurements) and biochemically before surgery and at one year after surgery. Results: Sleeve gastrectomy significantly decreased weight and body mass index (BMI), improves glycemic parameters, hyperfiltration, and urinary albumin excretion in diabetic and non-diabetic patients (P < 0.001). Alterations in C-reactive protein (CRP) levels are strongly associated with albumin-to-creatinine ratio (ACR) decline in diabetic patients. Conclusion: This study showed significant decreases in weight, BMI and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic individuals, accompanied by the resolution of hyperfiltration, urinary albumin excretion, and improvement of renal function by reduction of systemic inflammation.