Electrocatalytic detection of glutathione - The search for new mediators

Abstract

We report the possibility to use different mediators such as acetaminophen, 4-aminophenol, 4-amino-2,6-dichlorophenol and 4-amino-2,6-diphenylphenol to detect glutathione using a nanocarbon paste electrode. The detection is based on the electrocatalytic response involving the electrochemically generated quinoneimines and glutathione. 4-aminophenol is recommended as the most sensitive mediator in terms of giving the lowest limit detection of 0.80 μmol L-1.