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Sequence-specific recognition of double-stranded DNA by cooperative strand invasion.

Nucleic acids symposium series (2004) (2006) (50) 157-158
DOI: 10.1093/nass/nrl078
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Abstract

A remarkable feature of peptide nucleic acid (PNA) is its ability to recognize some sequences within duplex DNA by strand invasion. In order to improve binding properties of PNA triplex invasion, we tested the effect of cooperativity on the sequence specificity. A PNA targeting six bases within duplex DNA stringently recognized 12 base-pair homopurine site at a single base level.

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Sugiyama, T., Imamura, Y., Hakamata, W., Kurihara, M., & Kittaka, A. (2006). Sequence-specific recognition of double-stranded DNA by cooperative strand invasion. Nucleic Acids Symposium Series (2004), (50), 157–158. https://doi.org/10.1093/nass/nrl078

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