Recent development on the synthetic methods of chiral indoline derivatives

Abstract

The indoline skeletons, widely present in alkaloids and other products with diverse biological activities, which also have been considered as privileged structures due to their widespread use as building blocks and chiral auxiliaries in asymmetric synthesis. The importance of these motifs has determined that numerous synthetic multi-step strategies have been developed. Consequently, there has been a continuing interest in the development of efficient methods to obtain enantioenriched substituted indolines. A lot of methods have been introduced, including dynamic kinetic resolution, asymmetric reactions, asymmetric domino cascade reactions and other novel reactions. These methods have been reviewed. © 2012 Chinese Chemical Society and SIOC, CAS.