The Effects of Weight Loss on the Activity and Expression of Adipose-Tissue Lipoprotein Lipase in Very Obese Humans

Abstract

OBESITY is a complex condition characterized by disordered regulation of the energy balance.1 Although much research has focused on the behavioral, metabolic, and genetic aspects of obesity, the regulation of lipid deposition into adipose tissue is still incompletely understood. Lipoprotein lipase is an enzyme in adipose tissue that may be important for the regulation of body weight in several ways. In the capillaries of fat tissue, lipoprotein lipase hydrolyzes the triglyceride of circulating triglyceride-rich lipoproteins into free fatty acids. These free fatty acids are then taken up by the tissue, reesterified, and stored in the lipid droplets of adipocytes.2 Although . . .