Mycobacterium tuberculosis infection of end-stage renal disease patients in Taiwan: A nationwide longitudinal study

Abstract

End-stage renal disease (ESRD) patients are vulnerable to Mycobacterium tuberculosis (MTB) infection, but the magnitude of the risk is uncertain. In addition, there is no reliable information on the MTB infection rate of patients undergoing different types of renal replacement therapy (RRT). We used the Taiwan National Health Insurance Research Database to conduct a 9-year nationwide longitudinal study. Among 49983 ESRD patients who received three renal replacement modalities, there were 562 cases of MTB infection, corresponding to an incidence rate of 3.0 per 1000 patient-years. The risk of MTB infection relative to the general population was 4.5. Multivariate Cox regression analysis indicated that the independent risk factors for MTB infection in ESRD patients are old age (hazard ratio (HR) 1.17 per 10 years, p<0.001), male gender (HR 1.37, p<0.001), silicosis (HR 5.82, p<0.001), and chronic obstructive pulmonary disease (HR 1.68, p0.012). Hyperlipidaemia (HR 0.71, p<0.001) and hypertension (HR 0.81, p0.05) are associated with a lower infection rate. There was no effect of RRT modality on MTB infection rate. © 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.