Vitamin D Deficiency and the Presentation of Primary Hyperparathyroidism: A Mini Review

Abstract

Te clinical presentation of primary hyperparathyroidism (PHPT) has evolved over the years from a symptomatic disorder to a predominantly asymptomatic condition. Altered vitamin D metabolism seems to play a role in the presentation of PHPT and may exacerbate the severity of disease. Te epidemiology of PHPT difers in the developing versus the developed world, where more severe phenotypes occur in regions where vitamin D defciency is common. Although it has been validated that patients with PHPT should be vitamin D sufcient, the threshold to supplement in relation to the severity of PHPT and the degree of vitamin D defciency remains controversial. Tis review will highlight some of the controversy regarding vitamin D defciency and the diferent phenotypes of PHPT.