Anti-AIDS virus activity in vitro of dextran sulfates obtained by sulfation of synthetic and natural dextrans

Abstract

Anti-AIDS virus activity of synthetic and natural dextran sulfates was assayed in vitro by using a MT-4 cell line. These dextran sulfates with the number average molecular weight (Mn) of 1.8 × 104-10.7 × 104 showed potent anti-AIDS virus activity in the concentration as low as 3.3 or 10 μg ml-1, respectively. This high activity was almost the same as that of curdlan sulfates which was reported previously. The degree of sulfation per glucose residue in polymer backbone was 1.0-1.9 (the highest theoretical value is 3.0) which was calculated from the elemental analysis. Therelationship between the structure and anti-AIDS virus activity is discussed based on high resolution NMR spectroscopy. © 1993, The Society of Polymer Science, Japan. All rights reserved.