Synthesis and Bioactivity Screening of New 1, 3-Thiazolidin-4-One Compounds Bearing (Thiadiazols / Triazoles) Moieties

Abstract

This article deals with synthesis, Identification and biological activity screening of variety 1,3-thiazolidin-4-ones entitled 3,3'-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis[(5-methyl-2-(5-substitutedpyridine-2-yl)-1,3-thiazolidin-4-one)] 6a-d and 3,3'-[benzene-1,3-diylbis(5-mercapto-4H-1,2,4-triazole-3,4-diyl)]bis[5-methyl-2-(5-substitutedpyridine-2-yl)-1,3-thiazolidin-4-one], 7a-d. On cyclocondensation reaction of newly Schiff bases and thiolactic acid, some new derivatives of 1,3-thiazolidin-4-ones have been obtained in presence of anhydrous zinc chloride. The elemental analysis, proton NMR spectra of were outlined for structures confirmation. An agreement for the proposed structures of synthesized compounds were approved based on the elemental analysis, IR and 1H NMR spectra. Antimicrobial activity of the newly thiazolidinones have been evaluated with powerful results.