Confirmation of quantitative trait loci for ethanol sensitivity in long-sleep and short-sleep mice

88Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Initial insensitivity to alcohol is a strong predictor of human alcoholism, a widespread and heritable health problem. The Long Sleep and Short Sleep lines of mice were developed by genetic selection for high or low alcohol sensitivity. We have identified seven quantitative trait loci (QTLs) specifying differences in alcohol sensitivity using intercross progeny from these selected strains. These QTLs (Lore1-Lore7) together account for ~ 60% of the total genetic variance for this trait. This represents the first report of linkages for genes influencing alcohol action in ally mammalian system using stringent, genome-wide mapping criteria.

Cite

CITATION STYLE

APA

Markel, P. D., Bennett, B., Beeson, M., Gordon, L., & Johnson, T. E. (1997). Confirmation of quantitative trait loci for ethanol sensitivity in long-sleep and short-sleep mice. Genome Research, 7(2), 92–99. https://doi.org/10.1101/gr.7.2.92

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free