Acute Effect of Intraventricular Injection of Catecholamines and Indoleamines on the Secretion of 17-Oxosteroids by the Canine Testis

Abstract

Adult male dogs were injected into the third ventricle (3 rd V) with graded doses of catecholamines and indoleamines, and changes in secretion of testicular 17-oxosteroids by the testis were investigated for up to 2-4 hr after the injection. The secretion of testicular 17-oxosteroids was not affected by intraventricular treatment with 2, 5 and 10 μg of dopamine but stimulated slightly with 50 μg. The response was transient and occurred for up to 90 min after the injection. Intraventricular injection of 50 and 100 μg of noradrenaline or adrenaline had no stimulatory effect nor did it significantly alter the secretion of 17-oxosteroids by the testis for up to 120 min after the injection. Furthermore, serotonin and melatonin, given into the 3 rd V with doses of 5 and 50 μg, caused little or no secretion of testicular 17-oxosteroids. © 1973, Tohoku University Medical Press. All rights reserved.