Effects of acute organophosphate poisoning on glycemic profile in weanling rats

Abstract

Organophosphates (OP) are frequently used worldwide as pesticides in both agriculture and human households leaving toxic residues in food or living environment. OP act through acetylcholinesterase (AChE) inhibition and acute poisoning carries a higher risk of mortality due to parasympathetic overstimulation. Long-term exposure leads to nervous, hepatic or renal dysfunction. Chlorpyrifos, one of the most commonly used compound appears to cause hyperglycemia, insulin resistance and the risk of developing diabetes after prolonged exposure. The aim of this article was to assess the impact of acute OP poisoning on glycemic status in weanling mice.