P389Role of truncated plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy

Abstract

Introduction: Cardiovascular diseases remain a major cause of mortality in hemodialysis (HD). Oxi-dative stress may contribute to accelerated atherogenesis associated with hemodialysis. The objective of this study was to evaluate serum ferritin in chronic hemodialysis patients and search for clinical and biological characteristics association. Materials and Methods : This is a retrospective study of 45 chronic hemodialysis patients , 25 women and 20 men. We compared two groups of patients: G1 serum ferritin . 325 ng / ml and G2 ferritin , 325 ng / ml on: Clinical parameters: age, sex, initial nephropathy, during of dialysis. Biological parameters: hemoglobin (Hb), nutritional and inflammatory status (CRP, serum albumin, total cholesterol), serum calcium, phosphorus, Ca x P product. Comorbidities: diabetes , hypertension, cerebrovascular accident (stroke), coronary artery disease. Results and Discussion : The average age of patients was 51.26 + 15.21 years with a mean during of dialysis 1603 + 1207 months. The initial nephropathy was in 31% of cases chronic kidney disease asso-ciated with diabetes. Comparison of two groups G1 and G1 showed that advanced age, presence of cardiovascular disease (CVD), increased serum creatinine, fasting blood glucose, corrected calcium, phosphate (P) and LDL cholesterol were associated with elevated serum ferritin levels. Our results concord to the literature data and confirms that ferritin reflects a relative increase in the availability of iron and decreased antioxidant activity of specific iron and represents a risk factor for cardiovascular damage in hemodialysis advanced.