Evaluation of the choroid in eyes with retinitis pigmentosa and cystoid macular edema

Abstract

PURPOSE: To study the anatomical choroidal features associated with the presence of cystoid macular edema (CME) in eyes with retinitis pigmentosa (RP). METHODS: A total of 159 eyes (from 159 patients) with a diagnosis of RP were enrolled in this retrospective cross-sectional case-control study and divided into two groups based on the presence (67 eyes) or absence (92 eyes) of CME. Retinal and choroidal features were evaluated on spectral domain optical coherence tomography including central macular thickness (CMT) and subfoveal choroidal thickness (CT). Total choroidal area (TCA), choroidal luminal area (LA), and choroidal stromal area (SA) were measured and the choroidal vascularity index (CVI) was calculated in all study eyes. RESULTS: Average age was 49.2 6 14.9 and 47.1 6 15.5 years (P ¼ 0.40) and logMAR Snellen visual acuity (VA) was 0.4 6 0.6 (median 0.3, 20/40) and 0.2 6 0.4 (median 0.1, 20/25) in the RP groups with and without CME, respectively (P ¼ 0.05). Mean CMT was 334.1 6 93.5 and 252.6 6 47.6 lm in the RP groups with and without CME, respectively (P < 0.001). The subfoveal CT was significantly increased in the RP group with versus without CME (294.2 6 110.9 lm vs. 198.1 6 75.5 lm, respectively, P < 0.001). In patients with CME, the CVI was lower (P < 0.001) and the TCA, LA, and SA were all significantly higher (P < 0.001). CONCLUSIONS: In patients with CME associated with RP, the choroid exhibited significantly greater subfoveal thickening and decreased CVI. The choroid may be an important factor to consider in the etiology of CME in patients with RP.