EFFECT OF LOW MOLECULAR WEIGHT HEPARIN ON PREVENTION AND TREATMENT OF DEEP VENOUS THROMBOSIS IN ELDERLY PATIENTS WITH HIP FRACTURE AFTER OPERATION

Abstract

The aim of this research was to investigate the preventive and therapeutic effects of low molecular weight heparin (LMWH) on postoperative deep venous thrombosis (DVT) in elderly patients with hip fracture, and to explore its mechanism of action and safety. Fifty-four elderly patients with hip fractures admitted to the hospital were randomly divided into a treatment group and a control group (27 cases for each group). The treatment group was subcutaneously injected with LMWH while the control group did not receive LMWH. The visual analogue scale (VAS) score of the control group was significantly increased compared with the treatment group at 4 and 7 days after the operation. Haemoglobin level (HGB) and platelet (PLT) count in the control group were significantly increased compared with the treatment group at 7 days after the operation. The D-dimer level in the control group was significantly increased compared with the treatment group on days 4 and 7 after the operation. The postoperative drainage volume in the control group was significantly increased compared with the treatment group. The incidence of postoperative deep venous thrombosis (DVT) in the control group (62.96%) was significantly increased compared with the treatment group (14.81%). The results showed that the use of LMWH in elderly patients with hip fracture after the operation could significantly reduce the pain of the affected limb, reduce the plasma D-dimer content, inhibit PLT proliferation, promote HGB recovery, and reduce postoperative drainage volume, with high safety.