Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis

Abstract

Aim: Wound healing is a complex phenomenon with various biological changes in tissue integrity, low-level laser therapy (LLLT) has acquired several unique components to help into accelerating tissue reconstruction and eventually wound healing. Thus, in the present systematic review and meta-analysis study, the role of LLLT in oral mucosal wound healing following surgical interventions was investigated. Methods: The study databases, including PubMed, Web of Knowledge, Google Scholar, Scopus, and Cochrane, were searched by two blinded investigators considering eligible studies based on the following keywords: "Wound Healing", "Oral Mucosal Wound Healing", "Laser therapy", "Low-level laser therapy", "Oral Surgery", "Photobiomodulation therapy", among 88 screened, only 12 articles were eligible for the final analysis. Results: There was a significant difference between control and laser group in all mentioned studies in the case of wound epithelialization in gingiva, with weighted mean difference (MD) of -0.28, [95% confidence interval (CI): -0.37, -0.19, P < 0.001], periodontium 1 day postoperative, with weighted MD of -0.56 (95% CI: -0.84, -0.27, P < 0.001) and 7 days postoperative, with weighted MD of -0.73 (95% CI: -0.97, -0.49, P < 0.001). In the cases of postoperative pain, LLLT has significantly declined pain in comparison with control group with weighted MD of -0.47 (95% CI: -0.69, -0.24, P < 0.001) for 7 days postoperative and -0.55 (95% CI: -0.96, -0.13, P = 0.005) 14 days postoperatively. Conclusions: LLLT can be used as a promising tool in oral surgeries because of its inevitable capability in accelerating wound healing and reducing intraoperative pain.