Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene

504Citations
Citations of this article
188Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Fasting is associated with significant changes in nutrient metabolism, many of which are governed by transcription factors that regulate the expression of rate-limiting enzymes. One factor that plays an important role in the metabolic response to fasting is the peroxisome proliferator-activated receptor α (PPARα). To gain more insight into the role of PPARα during fasting, and into the regulation of metabolism during fasting in general, a search for unknown PPARα target genes was performed. Using subtractive hybridization (SABRE) comparing liver mRNA from wild-type and PPARα null mice, we isolated a novel PPARα target gene, encoding the secreted protein FIAF (for fasting induced adipose factor), that belongs to the family of fibrinogen/angiopoietin-like proteins. FIAF is predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. Moreover, FIAF mRNA is decreased in white adipose tissue of PPARγ +/- mice. FIAF protein can be detected in various tissues and in blood plasma, suggesting that FIAF has an endocrine function. Its plasma abundance is increased by fasting and decreased by chronic high fat feeding. The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions.

Cite

CITATION STYLE

APA

Kersten, S., Mandard, S., Tan, N. S., Escher, P., Metzger, D., Chambon, P., … Wahli, W. (2000). Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. Journal of Biological Chemistry, 275(37), 28488–28493. https://doi.org/10.1074/jbc.M004029200

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free