Restoration of effectiveness of β-lactams on methicillin-resistant Staphylococcus aureus by tellimagrandin I from rose red

  • Shiota S
  • Shimizu M
  • Mizusima T
  • et al.
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Abstract

We found that extract from petals of Rosa canina L. (rose red) strikingly reduced the minimum inhibitory concentration of L-lactams in methicillin-resistant Staphylococcus aureus. We isolated two compounds that reduced the minimum inhibitory concentrations of L-lactams from the extract, tellimagrandin I and rugosin B. Tellimagrandin I was very effective regarding the reduction of the minimum inhibitory concentration, and rugosin B showed some effect. Tellimagrandin I showed a weak bactericidal action when added together with oxacillin. Judging from the fractional inhibitory concentration index, the effect of tellimagrandin I and oxacillin was synergistic. Tellimagrandin I also significantly reduced the minimum inhibitory concentration of tetracycline in some strains of methicillin-resistant Staphylococcus aureus. ß

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Shiota, S., Shimizu, M., Mizusima, T., Ito, H., Hatano, T., Yoshida, T., & Tsuchiya, T. (2000). Restoration of effectiveness of Î2-lactams on methicillin-resistant Staphylococcus aureus by tellimagrandin I from rose red. FEMS Microbiology Letters, 185(2), 135–138. https://doi.org/10.1111/j.1574-6968.2000.tb09051.x

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