The frequency of revertants induced by 60Co γ rays of the ochre allele, cyc1-9, has been measured in radiation-sensitive strains carrying one of 19 nonallelic mutations and in wild-type strains. The results indicate that ionizing radiation mutagenesis depends on the activity of the RAD6 group of genes and that the gene functions employed are very similar, but probably not identical, to those that mediate UV mutagenesis. Repair activities dependant on the functions of the RAD50 through RAD57 loci, the major pathway for the repair of damage caused by ionizing radiation, do not appear to play any part in mutagenesis. A comparison between the γ-ray data and those obtained previously with UV and chemical mutagens suggest that the RAD6 'mutagenic pathway' is in fact composed of a set of processes, some of which are concerned with error-prone, and some with error-free, recovery activities.
CITATION STYLE
McKee, R. H., & Lawrence, C. W. (1979). Genetic analysis of gamma-ray mutagenesis in yeast I. Reversion in radiation-sensitive strains. Genetics, 93(2), 361–373. https://doi.org/10.1093/genetics/93.2.361
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