Abdominal aortic anuerysm and aortic occlusive disease: A comparison of risk factors and inflammatory response

Abstract

Objective: To compare patients with abdominal aortic aneurysm (AAA) and aortic occlusive disease (AOD) with regard to risk factors for atherosclerosis, co-morbid conditions and inflammatory activity. Patients and methods: A total of 155 patients undergoing abdominal aortic surgery between January 1993 and October 1997: 82 (53%) had aneurysmal disease and 73 (47%) had occlusive disease. Principal risk factors were compared: age; gender; smoking; hypertension; hyperlipidaemia; diabetes mellitus; severe peripheral vascular disease (PVD) and ischaemic heart disease. Aortic wall tissue samples were obtained during surgery. A prospective blind analysis was performed for the presence of inflammatory cytokines TNF-α, IL-1β, IL-6 and TGF-β. Results: The average age of AAA patients was 74 years (50-88), while that of AOD patients was 61 years (43-82) (p<0.0001). Diabetes mellitus was found to be much more prevalent in the AOD group (p<0.001), while hypertension and severe PVD were more prevalent in the AAA group (p<0.001). No differences were found concerning any of the risk factors. Inflammatory cytokine activity: AAA tissue sample contained significantly higher mean TNF-α and IL-6 levels compared to the AOD samples (5.6 ± 2.7 × 10E-4 vs. 4.4 ± 2.7 × 10E-5 atmoles/μl (p=0.01), and 0.6 ± 0.4 vs. 0.01 ± 0.006 atmoles/μl (p=0.02) respectively). No differences were found related to IL-1β and TGF-β. Conclusions: (1) Patients with AAA have fewer atherosclerotic risk factors than do patients with AOD. (2) Patients with AAA and AOD have significantly different inflammatory activity. (3) The data supports the hypothesis that AAA and AOD are probably two different pathological entities.