Neuronal N-type calcium channel blockers: A series of 4-piperidinylaniline analogs with analgesic activity

Abstract

Several novel N-type voltage sensitive calcium channel blockers showed high affinity in the IMR32 assay and efficacy in the anti-writhing model. Herein, we describe the design, synthesis, SAR studies, biological data, physicochemical properties and pharmacokinetics of this 4-piperidinylaniline series.