Retraction: Site-selective enzymatic C-H amidation for synthesis of diverse lactams (Arnold, Science 364, 575 (2019). (2019) 364 (575) DOI: 10.1126/science.aaw9068)

Abstract

After publication of the Report “Site-selective enzymatic C-H amidation for synthesis of diverse lactams” (1), efforts to reproduce the work showed that the enzymes do not catalyze the reactions with the activities and selectivities claimed. Careful examination of the first author's lab notebook then revealed missing contemporaneous entries and raw data for key experiments. The authors are therefore retracting the paper.