Synthesis, Identification and Antibacterial Activities of Amino Acid Schiff Base Cu(II) Complexes with Chlorinated Aromatic Moieties

Abstract

Amino acid Schiff base Cu(II) complexes were synthesized under microwave irradiation using methanol as a solvent, to maximize the best conditions to obtain the attained compounds, containing aromatics possessing no, one or two chlorine atoms. The compounds’ antibacterial activities were tested against Gram-positive and Gram-negative bacteria, and the most active were tested for their antioxidant activities, and as E. coli, in particular, was found to be sensitive to these compounds, their interaction with this bacterium was investigated. It was found that, depending on the amino acid used for the formation of the Schiff base ligand, its LogPo/w mono-chlorinated or bis-chlorinated compounds are the most efficient against the tested bacteria.