Solvent-free multicomponent assembling of aldehydes, N,N′-dialkyl barbiturates and malononitrile: Fast and efficient approach to pyrano[2,3-d]pyrimidines

Abstract

Potassium fluoride-catalyzed solvent-free multicomponent reaction of aldehydes, N,N′-dialkyl barbiturates and malononitrile results in the fast (15 min) and efficient (yields 89-95%) formation of substituted pyrano[2,3-d]pyrimidines. The improved synthetic methodology for this class of bioactive compounds is important from the viewpoint of diversity-oriented large-scale processes and represents an environmentally benign solvent-free synthetic concept for multicomponent reactions strategy.