The Immunologic Release of Constituents from Neutrophil Leukocytes

Abstract

The interaction of rabbit neutrophils with immune complexes induced release of constitutents to the outside of the cell. Two situations were studied. In one, the neutrophils adhered to immune complexes dispersed along nonphagocytosable surfaces; in the other, the cells were allowed to engulf phagocytosable particles coated with antibody or complement. In each case, release of constituents from the neutrophil granules occurred. IgG antibody was as effective in stimulating release of enzymes as was C3, although they react with different receptors on the neutrophil membrane. Smaller quantities of immunologobulins were required to induce release if bound to the nonphagocytosable surface than if phagocytosed by the neutrophils in suspension.