Green synthesis of 3,4-disubstituted isoxazol-5(4H)-one using Gluconic acid aqueous solution as an efficient recyclable medium

Abstract

Green synthesis of 3,4-disubstituted isoxazol-5(4H)-ones has been achieved via Knoevenagel condensation using three-component coupling reaction of aromatic aldehyde, ethyl acetoacetate and hydroxylamine hydrochloride in Gluconic acid aqueous solution (50 wt % GAAS). In this methodology, Gluconic acid aqueous solution used as reaction medium as well as catalyst and it can be recycled and reused several times without loss of its a significant efficacy. All compounds have been confirmed by 1H NMR, 13C NMR, IR spectroscopy and mass spectrometry.