Binding of platinum(II) to some biologicaly important thiols

Abstract

The reactions between [Pt(terpy)Cl+ and thiols, such as glutathione, L-cysteine, D-penicillamine and thioglycolic acid have been studied by conventional UV-VIS spectrophotometry and H NMR spectroscopy. The second-order rate constants, k2, are similar for these four thiols, varying between 1.06 × 10-2 and 6.10 × 10-3 M-1s-1 at 25°C. The activation entropies have large negative values between -100 and -200 J mol-1 which are compatible with an associative A mechanism. However, L-methionine, as thioether ligand, is unreactive under the same experimental conditions. The obtained results have been analyzed in relation to the antitumor activity and toxicity of platinum(II) complexes.