A Comparative Evaluation of Various Therapies of Synthetic Drugs with Amla and Honey Combination for the Treatment of Gastroesophageal Reflux Disease

2Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Background: Gastroesophageal Reflux Disease (GERD) is disorder of oesophagus that causes ulcer and erosion. Materials and Methods: A comparison based on the in vivo study was carried out to determine the therapeutic efficacy of herbal formulation using Amla and Honey in combination with Pantoprazole and Rebamipide for the treatment of GERD. The effects of all above mentioned medications were also checked on intestinal motility. In vitro studies were carried out to determine the antispasmodic activity of Amla and Honey in comparison to acetylcholine by isolated rat ileum. In pylorus ligation GERD model, mono-therapy was performed by giving herbal formulation of Amla and Honey. In combination therapy Pantoprazole and Rebamipide, Amla and Honey with Pantoprazole and Rebamipide were given and their therapeutic efficacy was observed at the ends of 14 days. In charcoal meal motility test the distance travelled by charcoal in intestine was measured. Results and Discussion: Combination therapy have highest therapeutic efficacy in comparison to mono-therapy of natural combination of Amla and Honey against Pantoprazole and Rebamipide. In vitro antispasmodic activity revealed that Amla and Honey formulation decreased the contractility pattern in concentration dependent manner against acetylcholine. In charcoal meal motility test highest intestinal motility were observed in Amla and Honey and can be given in GERD for easily digestion of food from stomach. Conclusion: Herbal combination of Amla and Honey in comparative evaluation decreases the Gastroesophageal reflux disease, intestinal mobility, and show anti-spasmodic activity in isolated rat’s ileum. However, these combinations serve as a more potential agent for decreasing all the factors responsible for the reflux disease.

References Powered by Scopus

Guidelines for the diagnosis and management of gastroesophageal reflux disease

1410Citations
N/AReaders
Get full text

The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association

622Citations
N/AReaders
Get full text

Honey: Its medicinal property and antibacterial activity

607Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Honey infused with herbs: A boon to cure pathological diseases

14Citations
N/AReaders
Get full text

Biomedical Perspectives of Herbal Honey

5Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Mazumder, A., Kumar, N., & Das, S. (2023). A Comparative Evaluation of Various Therapies of Synthetic Drugs with Amla and Honey Combination for the Treatment of Gastroesophageal Reflux Disease. Indian Journal of Pharmaceutical Education and Research, 57(2), 540–546. https://doi.org/10.5530/ijper.57.2.66

Readers over time

‘23‘24‘2502468

Readers' Seniority

Tooltip

Lecturer / Post doc 2

40%

Researcher 2

40%

Professor / Associate Prof. 1

20%

Readers' Discipline

Tooltip

Pharmacology, Toxicology and Pharmaceut... 4

67%

Chemistry 1

17%

Immunology and Microbiology 1

17%

Save time finding and organizing research with Mendeley

Sign up for free
0