Genetic analysis of susceptibility to isoniazid induced seizures in mice

Abstract

4 Sets of recombinant inbred lines of mice have been used to analyze genetic differences in acute toxicity of the drug, isonicotinic acid hydrazide. Standard inbred strains, their F1 hybrids and recombinant inbred strains were all challenged with a single dose of the drug. The % mortality of the different groups was analyzed to estimate heritability and the number of genes affecting resistance. The data indicate that resistance factors were dominant, heritability was moderate (.25 to .37), and more than 1 gene was involved in each of 4 different sets of recombinant inbred lines. Possible approaches for identifying and mapping individual genes affecting resistance are discussed.