Synthesis and antibacterial activity of N-acyl vancomycins

Abstract

Several glycopeptides containing N-acyl groups have been isolated recently. We undertook the synthesis of N-acyl vancomycins, using the active ester method. The in vitro and in vivo antibacterial activity were evaluated, and structure-activity relationship of this series of semisynthetic vancomycins is discussed. © 1988, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.