Coronin-1A epigenomics governs mycobacterial persistence in tuberculosis

Abstract

The lack of innovative therapies and the emergence of multi-drug-resistant pathogens emphasize the urgency of finding new approaches to fighting intracellular pathogens in general and Mycobacterium tuberculosis in particular, especially given the fact that tuberculosis is widely recognized as a major health problem worldwide. This review describes how host phagocytic cellular Coronin-1A gene epigenomics can be used to understand the subversive strategy adopted by M. tuberculosis to avoid encounter with the harsh environment within the phagocytic vacuole, and how it may provide a novel approach for the prevention and treatment of tuberculosis. © 2007 Federation of European Microbiological Societies.