Drug-induced hypersensitivity syndrome in association with varicella

Abstract

Drug-induced hypersensitivity syndrome (DIHS) is a severe multiorgan reaction related to the reactivation of human herpesvirus (HHV)-6 (1). Recently, the involvement of other types of HHV, including herpes simplex virus (HSV), Epstein-Barr virus (EBV), HHV-7, and cytomegalovirus (CMV), has been reported (2–5). We report here the first case of DIHS possibly associated with reactivation of varicella-zoster virus (VZV).