EXPLORATION OF THE ANTIOXIDANT AND ANTICANCER PROPERTIES OF METHANOLIC EXTRACTS DERIVED FROM FIVE DIFFERENT JASMINUM SPECIES, ALONGSIDE AN ANALYSIS OF THE PHYTOCONSTITUENT PROFILE USING GC-MS

Abstract

Several bioactive constituents found in conventional medicine possess antioxidant and anti-cancer effects and may be useful in the treatment of a variety of diseases, so the current study sought to conduct a thorough investigation of their potential use as a potent antioxidant and anticancer agent for five Jasminum species. The preliminary phytochemical analysis in a methanol extract of Jasminum indicated the existence of numerous bioactive secondary metabolites. More accurately, we discovered many novel compounds such deoxyspergualin, gentamicin B, cefazolin, cytidine, cycloheptanone oxime, folinic acid, 1-dodecene, epoxynonane derivative, dl-citrulline, thiocyanic acid, limonene 5,3',4'-trihydroxyflavone and 4-fluoro histidine. The results demonstrated that the plants have therapeutic values, since the extracts' antioxidant impact was examined using radical 2,2-diphenyl-1-picrylhydrazyl. The methanolic extract displayed varying half-maximal inhibitory concentration values slightly above the standard, indicating the significance of the bioactive metabolites present in the plant. Additionally, investigation was conducted on the potential anticancer properties targeting a specific liver cancer cell line and we revealed that J. azoricum was the powerful plant would effectively inhibit cancer cell lines at both 10 and 100 µg/mL.