Acetogenins of Annona muricata leaves: Characterization and potential anticancer study

Abstract

Annona muricata L. is belongs to the family Annonacea, which has been used in many traditional medicinal systems. It has many medicinal values such as to cure fever, headaches, cough, asthma and hypertension. Such bioactive chemical compounds identified through characterization compounds analysis. The analysis of bioactive and acetogenins compounds in the crude plant extracts involving the applications of common identification and characterization technique involving nonchromatographic techniques such as phytochemical screening and metabolites quantification, Nuclear Magnetic Resonance (NMR) and Fourier-Transform Infrared (FT-IR) along with chromatographic technique such as High Performance Liquid Chromatography (HPLC) are discussed. The evaluation of cytotoxicity study on normal and cancer cell lines was accessed with no alteration occurred in the normal Periodontal Ligament (PDL) cell line and showed some inhibition in colon cancer (HT-29) cell line. The presence of bioactive compound is confirmed as the valuable medicinal compound likely to cure vast array of disease.