Abstract
AlbA is a radical SAM enzyme catalyzing the formation of three unusual thioether bonds in the antibiotic subtilosin A. We demonstrate here that AlbA catalyzes direct Cα H-atom abstraction and likely contains three essential [4Fe-4S] centers. This leads us to propose novel mechanistic perspectives for thioether bond catalysis by radical SAM enzymes.
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CITATION STYLE
APA
Benjdia, A., Guillot, A., Lefranc, B., Vaudry, H., Leprince, J., & Berteau, O. (2016). Thioether bond formation by SPASM domain radical SAM enzymes: Cα H-atom abstraction in subtilosin A biosynthesis. Chemical Communications, 52(37), 6249–6252. https://doi.org/10.1039/c6cc01317a
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