Mutagenicity of N-acylglycinohydroxamic acids and related compounds.

Abstract

The mutagenic activity of twenty-nine new N-acylglycinohydroxamic acids and related compounds was tested on Bacillus subtilis (Rec+, Rec-) and Salmonella typhimurium (TA 98, TA 100). All the N-(substituted-benzoyl) glycinohydroxamic acids, except 3-acetylaminobenzoyl-derivative, were shown to be mutagenic to both test bacteria, whereas most of the N-aliphatic acylglycinohydroxamic acids were found to be non-mutagenic. In the present study, we discussed our observations focussing on the structure-activity correlation between their chemical structures and mutagenic activities. © 1980, The Pharmaceutical Society of Japan. All rights reserved.