Synthesis of 4-aryl-4,5-Dihydro-1H-Indeno[1,2-d]pyrimidines by Biginelli condensation and their antibacterial activities

Abstract

A simple and efficient method has been developed for the synthesis of series of 4-aryl-1,3,4,5- tetrahydro-2H-indeno[1,2-d]pyrimidine-2-thiones through Biginelli's one-pot multicomponent condensation reaction via microwave irradiations. Then, these thiones were converted to their S-alkylated/ aralkylated derivatives. The prepared heterocyclic products were structurally confirmed by analytical and spectral data and evaluated for their antibacterial activities. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The compound 2-(Ethylthi1 (o) -4-(4-Hydroxy-3-methoxypheny1 (l) -4,5-dihydro- 1H-indeno[1,2-d]pyrimidines 4b have shown antibacterial activity towards all the seven clinical isolates used. © Indian Academy of Sciences.