The P-value illusion: How to improve (psychiatric) genetic studies

Abstract

There is an emerging appreciation that genome-wide association studies (GWAS) have failed to live up to expectations and deliver major advances to date. A "surge" strategy, of pooling resources and increasing number of subjects tested, is underway.Weargue that, while useful, itwill not be enough by itself. Complementary approaches are needed tomine these large datasets.Wedescribe a series of problems, opportunities, and offer a potential comprehensive solution. © 2010 Wiley-Liss, Inc.